If I am to isolate peripheral exosome for analyzing their protein content, which sample type is more advisable, plasma or serum?
Hi, It's better to go with Plasma than Serum. Coagulation might affect your exosomes extraction.
Serum will be better and you can do Elisa to check both qualitative and quantitative as wel. As you have mentioned protein term.
IF I WERE YOU I WOULD GO WITH SERUM
Plasma is better, bacause during preparation of serum, more content of dying cells can be released and falsely affect your results.
plasma might be better, but its trickier to isolate clean exosomes from plasma vs serum
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