Comparison of the proportion of subjects consuming alcohol or in the the lowest tertile of the dapsone recovery (DPRR) between controls and patients with aggressive bladder cancer showed a 7-fold increased of relative risk in the latter group.
On the other hand, prominent adverse effects seen during treatment with dapsone are hemolysis and methemoglobinemia. The highest methemoglobin formation with dapsone was observed with CYP2C19, with minor contributions from CYP2B6, CYP2D6 and CYP3A4.