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Questions related from Ilya B. Tsyrlov
Adverse health effects from Rotenone have been well documented in the time since the NOSB reviewed botanicals in 1994. But still Rotenone is continue to be used for organic production. Although no...
10 April 2021 8,187 2 View
In the late 1970s - beginning of the 1980s, we’d developed a pioneer approach to prepare antibodies against monooxygenase molecular isoforms without laborious purification of CYPs. To achieve the...
26 May 2016 8,183 1 View
Just recently, features of psychiatric disorders such as schizophrenia were suggested to be due to a decrease of brain memory center’s inhibitory neurons. HSV-infection is primarily limited to...
08 January 2016 9,046 6 View
Some data on catechol O-methyltransferase inhibitors and dopamine agonists all refer to in vitro studies of the drugs. As for in vivo situations, for example, a synthetic ergoline dopamine agonist...
28 November 2015 7,520 1 View
My previous attempt to raise this point was misdirected to the data on hydrophobic zone(s) in protein moiety of P-450 (CYP) influencing its active center’s substrate-binding and catalytic...
07 November 2015 6,202 2 View
Technically, competitive and noncompetitive inhibitors all can bind to an allosteric site, although most competitive inhibitors bind to the active site. The discrepancy explains by the...
23 October 2015 9,447 4 View
Aspirin and numerous NSAIDs, including acetaminophen and those inhibiting selectively COX-2, are amongst the most commonly consumed drugs on the planet. Aspirin at doses less than 100 mg per day...
03 October 2015 2,831 6 View
In the 1980s, the above point served as the major reason for the development of centrilobular necrosis after administration of compounds which require metabolic activation. Centilobular...
27 August 2015 7,574 3 View
Comparison of the proportion of subjects consuming alcohol or in the the lowest tertile of the dapsone recovery (DPRR) between controls and patients with aggressive bladder cancer showed a 7-fold...
10 June 2015 8,469 1 View
All the above factors might be involved, although the prevailing factor is drug-drug interactions in drug addicts infected with HIV, namely the following drugs competing with each other at the...
22 May 2015 9,356 1 View
Only mutations in NEMO have been identified as the main genetic basis for several devastating human diseases, including immunodeficiency. A large number of patients have deficient antibody...
04 May 2015 1,452 3 View
One of explanations might be that tumor microenvironment is enriched with inflammatory cells accumulating extremely hydrophobic compounds, such as bodily dioxin, a high-affinity ligand for the Ah...
13 April 2015 8,361 3 View
DHR96 might be activated by phenobarbital, while AhR - only by planar PAHs and dioxins. So, DHR96 might be a predecessor for the AhR able to be activated by bulky and less hydrophobic xenobiotics.
15 March 2015 6,845 1 View
Famous Koshland theory was developed for water-soluble enzymes (99% of all)/ Some vital enzymes, like cytochrome P450s, are embeded into phospholipid matrix of microsomal (endoplasmic reticulum)...
10 March 2015 3,600 5 View
Colleagues, please help me correct a long existing problem with misprinted last name in the beneath paper in Carcinogenesis (1994), where instead of Tsyrlov people at Oxford Academic printed...
01 January 1970 3,396 4 View
On the 25th of August' 2025 our New York Corporation completed 20 years of its establishment (Xenotox Inc.pdf). While celebrating an anniversary of the company, I would like to take this...
01 January 1970 8,025 0 View
