Recommend please an article where the mentioned protocol is giving the possibility to maximize the affinity to target sequence.
Is there any complex approach of LNA sequence customization/modification for different miRNAs of circRNAs?
We are looking for the datasets that can be used for evaluating fairness models in machine learning on real data. Could you recommend a labeled dataset in which the labeling reveals some unfair...
11 November 2020 649 8 View
04 June 2020 2,254 1 View
I need to simulate an ion surrounded by water molecules using periodic boundary conditions using VASP. I understand, that due to waveplane basis set nature we can't set charge to particular atom....
15 January 2020 6,428 2 View
Dear colleagues, I need to determine the crosslink density of thermosetting cyanate ester resin. Among the methods, which are presented in the literature, I chose the solvent-swelling method. For...
01 October 2019 7,302 1 View
Hi there. I want to extract separately cytoplasmic and nuclear RNA fraction from leukemic cell line by Trizol. Most of protocols that I saw suggests using a buffer with NP-40 or Triton X-100 for...
06 September 2019 2,257 3 View
Hi everyone! Im going to study about magnetic permalloy disks and their vortex state. Specially, Im interesting in disks of 1,5 um in radius and 20nm of thick. But i want to get a knowledge...
25 August 2019 4,690 3 View
Has anyone used a cheap commercially available brain computer interface, such as "NeuroSky MindWave", or "Muse: The Brain Sensing Headband" in the learning process, in gamification? Are works on...
10 July 2019 2,863 1 View
I am trying to perform Ab Initio molecular dynamics simulation for liquid 5-component system (TiZrNbHfTa alloy). And when I'm trying to perform it with the default value of PAO.Splitnorm (=0.15),...
22 January 2019 8,164 1 View
On larva or adult stages. Do you have any ideas about automating this process?
07 July 2018 4,765 3 View
Do you have some thoughts about automation of process? Smth like: 'Insects as Sustainable Food Ingredients ' https://bit.ly/2Kacfdc
26 June 2018 1,457 2 View
I am a little confuse with the mechanism of solid lipid nanoparticles (SLNs). The main point of encapsulating drugs into SLNs is because some drugs have low solubility in water. Therefore, SLNs...
01 March 2021 3,703 3 View
Hello, I was just wondering how does a antibody have full intact antibody + half antibody? Is it because of the drug conjugation?
28 February 2021 1,577 1 View
Dear All, mirna primer showing some problem in the melting curve? any idea why? As attached is the melting curve. The forward sequence is obtained from miRBase and reverse primer is universal.
28 February 2021 5,008 4 View
I am learning how to use SPM for PET and PET-MR analysis, but I haven't found any great resources that explain how contrasts work. I have a series of PET images where our hypothesis argues that...
24 February 2021 1,534 2 View
In diseased conditions, many genes and gene products are visible in the bloodstream. So my question is whether we can find traces of microRNA which is involved in disease and disorder in blood serum?
24 February 2021 7,064 3 View
When dealing with bacterial toxins, there are three varieties of microbes that develop in your petri dish: toxic, resistant, and susceptible. Initially, there are only toxic and vulnerable...
21 February 2021 6,084 5 View
Detecting the drug related problems is an important step in the pharmaceutical care plan
21 February 2021 5,421 3 View
Hello RG community, I wonderer whether exogenous molecules (e.g. reporter plasmids, miRNAs or other artificial molecules) are transferred between cultured human cells during their doubling ? So,...
21 February 2021 6,633 3 View
19 February 2021 8,647 3 View
I have made neosome from herbal drug. Neosomes are stable. But I face problems in dissolution. I used minimum ratio of 1:1:0.25 ( Drug:span 60: Cholesterol and GMs. Now how can I active better...
17 February 2021 3,584 1 View