Hi, In the process of histidine metabolism 4-imidazolone 5-propionate gets converted into N-Formimimino Glutamate (FIGLU) with the help of 4-imidazolone 5-propionase enzyme. I want to know whether this reaction is uni or bidirectional?
Hi!
It is a bidirectional reaction
https://www.genome.jp/dbget-bin/www_bget?K01468+3.5.2.7+R02288
Bidirectional.
https://www.brenda-enzymes.org/enzyme.php?ecno=3.5.2.7
Hi there,
Any chemical reaction is potentially reversible (depending on the conditions)! Do you mean the reaction is happening in both directions in a cellular context? Well, the reaction you mention acts only in the histidine degradation pathway and implies the opening of the imidazole derivative ring through hydrolysis. Therefore the prevaling reaction is the one producing the glutamate derivative.
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