Actually I am not able to understand that during the synthesis of a molecule if I do disconnection and try to make the molecule by cross coupling reaction then which part I should consider as aryl halide and which part as boronic ester in case Suzuki coupling.
The aryl halide is the electrophile in the coupling reaction, so you should select the more electron-withdrawn partner as the halide, and the more electron-rich partner as the boronate (the nucleophile.)
This assumes that all four possible reactants are available at comparable expense. The coupling is reliable enough to let you choose on the basis of cost, which you might want to do if working on a large scale.
A good overview can be found at Article Selection of boron reagents for Suzuki–Miyaura coupling
- Badges
- Science method