I used a Domiphen Bromide in the concertation of 0.025 w/v as preservative in the oral liquid formulation.
Its effectiveness has been proven by the Antimicrobial Efficacy Test.
Is it used concentration in the range of recommended concentrations for this preservative.
The concentration used as preservative provide a significant concern as it is also a proven anti-infective with an therapeutic abilities in clinical trial.
The efficacy and tolerability of domiphen bromide (domifen bromide), administered at a dosage of 0.5 mg every 4-6 hr in a double-blind placebo controlled study in 31 patients affected by acute infectious dental diseases, are described. After 2 days of treatment with the drug, there was a significant decrease in pain and inflammation. The drug elicited a good response, improved prognosis and reduced the number of days of illness.
When the preservative agent selected is domiphen bromide a concentration between 0.005% and 0.2% by weight/volume can be used.https://patents.google.com/patent/EP1757294A1/en. Thank you.
Dear Saurav,
Thank you very much for your reply. This information is a confirmation that the concentration I used is within the prescribed range.
Best regards, Ljiljana
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