Hi Karol,

It's probably worth a try. Alternatively, you could also try subcellular fractionation and comparing cytoplasmic to nuclear B-cat. We have done it in colon here:

Article RAL GTPases Drive Intestinal Stem Cell Function and Regenera...

but is has also been done in some lymphoma cell lines eg here:Article Constitutive activation of the Wnt canonical pathway in mant...

You will probably want to incorporate the use of a Wnt ligand and a Wnt inhibitor to give you a bit more confidence that your tecnique works and some idea about its sensitivity.

I would imagine that you are likely to run into some issues comparing between different cell lines if they cover a wide range from the endless list of lymphoma subtypes available.

Also, depending on what you find and where you aim to take your project, you may be asked by reviewers to confirm your findings more quantitatively further down the line. I would probably start optimizing this sooner rather than later.