A CASE OF recurrent sqamous cell carcinoma lower third esophagus. She received radiochemo. in the 1st presentation 3 years ago. Does she need a 2nd neoadjuvant therapy prior to surgery?

What is meant by complete response to radiochemotherapy and how many biopsies are needed to prove this? and is there any role for surgery in non complicted complete responders to radio or chemo? 

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