Hi all,
I am interested in using hemodynamic based functional imaging tools (ultrasound, photoacoustic, optical coherence tomography, etc) to measure the activity of axon fiber groups in large nerve branches (e.g., vagus, sciatic) in large animals and humans. The question I have is "how is the relationship of neurovascuar coupling in these major nerve trunks?". Since I could not find much data or observations, I look into the white matter of the spinal cord which might be a good analogy. What I found so far is the capillaries are five times less dense compared to grey matter, and still uniformly distributed. With that in mind, I would guess, there is still some degree of neurovascular coupling that exists, however, I am wondering how local such a relationship is and whether it can be a surrogate measure of axonal activity.
Would appreciate any reference that has relevant information!
Consider axonal current flow with the flow of other ferromagnetic materials such as red blood cells. see the section titled Brain Electromagentism in my paper.
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