A single dose of clindamycin rarely causes Clostridioides difficile (C. diff) colitis, but the risk is not zero. Clindamycin is among the antibiotics most strongly associated with C. diff due to its effect on gut flora. Most cases occur after prolonged or high-dose use, especially in older or hospitalized patients. However, individual susceptibility varies, and even short courses can trigger C. diff in vulnerable people. Monitoring for symptoms like diarrhea after antibiotic use is important, regardless of dose.

Thank you Suraj Kapoor . Do you recommend any studies that specifically investigated this topic?

A retrospective cohort study reviewing medical records of patients given single-dose clindamycin could assess incidence. Feasibility is high with access to hospital records, infection control data, and lab results. Ethical approval and proper case definitions would be essential.

That is a nice idea. Are you aware of any published data Suraj Kapoor?