Thank you for the above important question. After going through the literature, I would advise you not to use Hep-2 cell line for your research in laryngeal cancer because Hep-2 is in fact comprised of cervical adenocarcinoma cells, derived via HeLa cell line contamination. This was shown by Stan Gartler in 1966 and published in 1968. Later this cell line was subsequently confirmed via PCR to be positive for human papillomavirus DNA sequences.
For more information you may want to refer the following articles attached below.
Article A comprehensive review of Hep-2 cell line in translational r...
Article Reevaluation of HeLa, HeLa S3, and HEp2 karyotypes