Due to that the DNA methylation and the RNA methylation could both regulate the gene expression, so here is my confusion: does the DNA methylation have the effect on RNA methylation? For example, the gene CDO1 is hypermethylated at the CpG island in LUAD, dose this DNA hypermethylation effect the RNA methylation pattern or level? By the way, these two kinds of methylation has the same effect on gene expression or not? And which is the key regulator to the gene expression?
1.RNA methylation is dependent upon the methylation motif say ggacc.THere is separate set of proteins called writters ,reader ythdf2 and erasers of methylation of RNA.
2.for DNA methylation it depends upon dnmt1,
3.so say DNA methylated in cpg island and there are proteins called mbd which bind methylation mark ,mbd can also bind up with RNA
And influence the methylation of DNA.
4.so RNA directed dna methylation exist
5.mirna also elfluence methylation of mRNA,
so RNA directed RNA methylation exist
6.dna directed RNA methylation not explored
You have to take into account a methylated promoter is inhibited from transcription so no mRNA from that gene in the most case. There can be another gene on the other allele but it may not be methylated but its a good question.
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