Hi James.
I don't know definitively, but I see no reason why it wouldn't. SOD3 is generally higher in the EC matrix than EC fluids. I'd look for info on its expression levels in muscle tissue and neurons. Not sure if this helps:
http://www.proteinatlas.org/ENSG00000109610-SOD3/tissue
Cheers.
Alex
Hi Alex,
Many thanks for your kind response. I will look into the link. Generally, gross expression data in tissues can belie restriction from certain sites (a false positive if you will). I think it could be present. Motor neurons express a NOX which appears to be present at the terminal so one has a site of extracellular O2.- generation into the cleft so perhaps makes sense to have a dismutase present. However, I was thinking EcSOD could interfere with synaptic transmission just by its presence- another protein making a potential collision site for ACh. Although with over 10,000 ACh released per vesicle- it shouldn't make too much difference.
All the best,
James
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