I wonder if isolated myeloid sarcoma without bone marrow involvement has a poor prognosis and patients need to undergo allogeneic hematopoietic stem cell transplantation.
Dear Mojtaba,
Check this out:
Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation
Patrice Chevallier, Myriam Labopin, Jan Cornelissen, Gérard Socié, Vanderson Rocha, Mohamad Mohty
Haematologica. 2011 September; 96(9): 1391–1394.
Dear Dr Mojtaba Akhtari
Myeloid sarcoma or other extramedulary presentations of acute leukemia with or withouth BM involvement usually are treated by HSCT,because this manifestations are indicator existence of sanctuary site that MRD couldn,t detect blast cells in it.Also chemotherapy drugs trend to transfer to sites posses crawded blast population .Therefore BM and facilitated sites are cleared sooner than other hidden sites with low cellularity of blasts.
Dear Mojtaba
Extramedullar leukemia has to be treated as AML - that means chemotherapy for induction and consolidation therapy, according to your centre protocol. If patient has sibling donor I should strongly recommend alloTx. If not even auto Tx seems rational approach.
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