20 Questions 42 Answers 0 Followers
Questions related from Mojtaba Akhtari
I am treating a young patient, who has relapsed B-ALL, with Blinatumomab. The patient has developed cholestatic jaundice. Bilirubin has raised to more than 6.0 and alkaline phosphatase to more...
26 May 2016 2,087 2 View
Patients with HLH can have severe neutropenia. When you treat them with Etoposide and Dexamethasone, is there any role for using G-CSF?
19 November 2015 499 4 View
I have a young patient who was getting chemotherapy and radiation for relapsed Ewing's sarcoma. The patient started having pancytopenia and a bone marrow aspiration and biopsy showed AML. The...
13 August 2015 3,221 7 View
I have a young patient with hepatosplenic T-cell lymphoma. He had 4 cycles of CHOEP, he progressed; then he had 4 cycles of SMILE with PEG-Asparaginase, and he progressed. He received 1 cycle of...
04 August 2015 3,284 4 View
I wonder if isolated myeloid sarcoma without bone marrow involvement has a poor prognosis and patients need to undergo allogeneic hematopoietic stem cell transplantation.
30 June 2015 8,146 3 View
I have a patient who was on Adalimumab and developed pancytopenia and hypoplastic bone marrow. His severe neutropenia improved with using G-CSF and his pancytopenia resolved after 1 month. Has any...
25 May 2015 263 2 View
I have a young patient with hepatosplenic T-cell lymphoma. He had 4 cycles of CHOEP, he progressed; then he had 4 cycles of SMILE with PEG-Asparaginase, and he progressed again. His performance...
19 May 2015 1,036 5 View
I have a patient with relapsed t-ALL after allogeneic hematopietic stem cell transplantation (AHSCT). She had received hyper-CVAD, Nelarabine, ICE and PEG-Asparaginase before we performed AHSCT...
12 April 2015 1,523 9 View
Blinatumomab infusion causes high fever which is sometimes hard to control, and I wonder if anybody has used Dantrolene to control high fever even if CK is in the normal range?
09 March 2015 8,056 2 View
I wonder what the best strategy would be to control the rising blast count in the first week of starting Blinatumomab in a patient with refractory ALL?
06 March 2015 1,950 6 View
We have a patient with relapsed acute myeloid leukemia (AML) after a myeloablative (Busulfan/Fludarabine) HSCT, and our plan is to take her into a 2nd HSCT. Can we take her to a 2nd myeloablative...
02 February 2015 2,972 10 View
Is there any evidence that blood transfusion increase the risk of GVHD in patients post hematopoietic stem cell transplantation?
20 January 2015 3,821 5 View
What are the practical ways to manage erythematous skin rash due to Azacitidine? This is different from skin irritation at the injection site, which is usually mild and self-limited. I have seen...
05 January 2015 9,358 3 View
What is the optimal induction regimen for patients with biphenotypic acute leukemia? Should they be treated with AML-type or ALL-type induction regimens?
23 December 2014 8,643 24 View
Is there any role for elective splenectomy before allogeneic hematopoietic stem cell transplantation in patients with CMML who have massive splenomegaly?
21 December 2014 853 5 View
Does leukapheresis reduce early mortality in acute myeloid leukemia, and at what white blood cell count (WBC) should we start leukapheresis, WBC > 50,000 X 109/L or WBC >100,000 x 109/L?
14 December 2014 6,095 11 View
There is evidence that AML patients with positive FLT3 ITD can benefit from Sorafenib, and I wonder if we need to add Sorafenib to the therapeutic regimens for patients with AML who are positive...
28 November 2014 7,811 2 View
Do you administer induction chemotherapy such as 7+3 for myeloid sarcoma in fit patients who can tolerate it? What is the best way to treat myeloid sarcoma?
18 November 2014 2,664 16 View
For adult patients with ALL which regimen you prefer (1) Pediatric type or BFM-like protocols or (2) Hyper-CVAD? Does anybody think that Hyper-CVAD is more toxic and associated with unnecessary...
08 November 2014 8,687 8 View
Do they need potent chemotherapeutic regimens such as Hyper-CVAD? What is your opinion about combination of Dasatinib and PEG-Asparaginase for adult patients with ALL, Ph+? Do you think the...
31 October 2014 4,631 6 View
