ErbB3, also called Her3 (human epidermal growth factor receptor 3), is a type 1 membrane glycoprotein that is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 consists of several secondary structures such as alpha-helices, beta-strands, and random coils. At least 5 different isoforms of ErbB3 have been identified and described. One isoform of this ErbB3 protein is merely secreted outside the cell unlike the membrane protein described above. This secreted isoform is believed to modulate the activity of the membrane protein isoform of ErbB3 and has been found to modulate neuroglial function and growth. This isoform is often upregulated in glioblastomas and Schwannomas. The structure of ErbB3 also has bound Mg2+ and AMP-PNP. The bound Mg2+ ion is coordinated by the side chains of amino acids N820 and D833 and α- and β-phosphates of AMP-PNP. The ions and the phosphate groups act together in aiding many phosphorylation activities. Lin and Cheng (2008) established that p45-sErbB3 is a structurally and functionally unique gene product of ErbB3 and suggest that p45-sErbB3 is likely one of the factors involved in the osteoblastic bone metastases of prostate cancer.
Oncogene. Sep 4, 2008; 27(39): 5195–5203. Full article available at
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562662/
Hsieh et al found that Secreted ERBB3 Isoforms are serum markers for early hepatoma and clear marker in differential diagnosis for early hepatocellular carcinoma in patients with chronic hepatitis and cirrhosis.
J. Proteome Res., 2011, 10 (10), pp 4715–4724
You can try to have a look to this paper.
Journal of Histochemistry & Cytochemistry
http://jhc.sagepub.com/content/48/1/63
The online version of this article can be found at:
DOI: 10.1177/002215540004800107
J Histochem Cytochem 2000 48: 63
M. Ip
Kathleen M. Darcy, Danilo Zangani, Ann L. Wohlhueter, Ruea-Yea Huang, Mary M. Vaughan, Joy A. Russell and Margot
Normal Rat Mammary Epithelial Cells
Changes in ErbB2 (her-2/neu), ErbB3, and ErbB4 during Growth, Differentiation, and Apoptosis ofNormal Rat Mammary Epithelial Cells
- Badges
- Science topic