Do any one have a list of cell lines that are non-permissive to Dengue virus infection?
As we all know that the Dengue virus is RNA based its penetration in a given cell is really not the issue, what to say of non-permissible cell line. The viral RNA interjection into a given cell is only productive when it's RNA survival infrastructure available in the cytoplasmic arena, moreover, it's sustenance to survive, mature and proliferate. Do you think there exists in a living body a line of (Non-Permissive) cells that don't have biogenic characteristics?
I don't think so. Even hair cells have living characteristics that any virus can sustain in for a shortest period of time. Dengue virus was thought to be only survivable in the liver. Look what does it do to the brain. While we were busy saving lives in 2011 epidemic in Lahore, Pakistan, Indians were studying its neurological manifestation. Sure enough, we traced its behavior and successfully interrupted its life cycle and established "Zero Mortality", Published and listed here in my profile.
One has to still study its behavior and life cycle after injection in the human body.
Our research center is open for scientific collaboration for any institution to further the study on the Dengue and Zika virus.
Best Regards
Prof. Shahid H. Sheikh
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