Hello ResearchGate Community,
I am currently working on my final year undergraduate project, which involves the compression testing of tissue scaffolds, specifically focusing on neural and bone tissues. Due to limitations with 3D bioprinting, I am unable to fabricate actual tissue scaffolds and am thus seeking alternative materials that closely mimic the mechanical properties of these tissues for testing purposes.
Project Overview:
My project aims to analyze the compression resistance and mechanical behavior of tissue scaffolds, with a particular focus on neural and bone tissues. The main challenge I'm facing is identifying suitable substitute materials that can be fabricated (preferably using accessible methods) and used for compression testing to simulate the real mechanical properties of these tissues.
Questions:
1. Material Suggestions: Could anyone recommend materials that have been successfully used to mimic the mechanical properties (such as elasticity, compressive strength, etc.) of neural and bone tissues in compression tests?
2. Fabrication Techniques: Are there specific fabrication techniques (aside from 3D bioprinting) that you have found effective in creating these surrogate materials with properties that are comparable to the actual tissues?
3. Testing Protocols: I would also appreciate any insights or references to standard testing protocols for conducting compression tests on these materials to ensure the results are as reflective as possible of how the actual tissues would behave under similar conditions.
Additional Context:
I am conducting this project as part of an exchange semester in Australia and face the challenge of working independently with limited direct guidance. Thus, any advice, especially from those who have navigated similar projects or have expertise in biomaterials and tissue engineering, would be immensely helpful.
Thank you in advance for your time and assistance. Your insights will not only aid in advancing my project but also contribute significantly to my learning experience in this fascinating area of research.
Best regards,
Anupama
Some articles that appear to be related:
https://www.sciencedaily.com/releases/2021/08/210830163949.htm
https://www.eurekalert.org/news-releases/1007529
https://www.sciencedirect.com/science/article/abs/pii/S1742706113005576
https://www.sciencedaily.com/releases/2021/06/210623130654.htm
https://newatlas.com/biohybrid-hydrogel-cartilage-replacement/
https://www.innovations-report.com/materials-sciences/report-6192/
https://www.innovations-report.com/materials-sciences/self-healing-bone-cement/
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Regards,
Joachim
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