On seeing the ethical issue i have turn towards to do study in normal liver and kidney cells.Therefore could anyone suggest normal liver and kidney cells to carry out my studies.
Dear you want to do Toxicity studies pertaining to Liver and Kidney, in my view if it is toxicity studies then see the "0" day Kidney Function Test(KFT) and "0" day Liver Function Test (LFT) and later administering test drug again see the KFT and LFT after 28 days or 90 days as per your toxicity protocol.
Respected Sir
Thanks a lot for your valuable information. I would like to do toxicity in liver and kidney cells.i' m going to induce my toxic chemical in liver and kidney cells, later I will treat the cells with chemical and plant extract.I ' m going to carry out these in studies in normal liver and kidney cells.
Dear Shaista,
It depends on you want "early detect signs" or "failure sign to study"? I recommend that you do the previous to make it more valuable to people's health.
When starting repeating wake up between 1-3 AM, easily get mad, headache on the top of the head, etc. are all liver problems indications.
Kidney problems cover waist soreness or weakness or pain, hard to control pi or Pu, lower limb circulation problem, etc.
If you really want to study as I recommend, I can give you more symptoms.
Happy New Year!
Frieda
Mam
I want to do in vitro on cell line. Getting ethical number is itself an issue.Moreover my minimum period is also over Therefore I prone to carry out my toxicity study in normal liver and kidney cells.
Thanks man i' m concentrating on HepG2 and RCC for toxicity study. Let's see how much inhibition effect is there in my plant extract.
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