Dear Akhilesh Naik , It actually depends on the purpose of your research. If it is only for docking purpose, optimization through Avogadro might work. But, I have seen in most of the high quality articles, researchers using Gaussian for energy optimization of small molecules before docking. In fact, if you are adding QSAR studies in your research, then optimization through Gaussian is better.

Prasenjit Bhowmik Thank you soo much. I'll look into both the softwares.