Is there any (validated or not yet) evaluation form available for formally assessing the causal relationship in a treatment-emergent mortality?

Is there any (validated or not yet) evaluation form available for formally assessing the causal relationship between a complex treatment and a subsequent treatment-emergent (or hopefully not)...

05 June 2018 7,585 0 View

Why EMBASE literature database is such unfriendly and not accessible?

I'm so frustrated in accessing EMBASE for scientific research. High expense and poor accessiblity. I don't know how and why the EMBASE leads me into this negative impression?

08 September 2015 7,489 0 View

Any caveats that should be kept in mind beforehand while using the Jointpoint regression model to calculate the trends of certain cancer occurrence?

Any caveats that should be kept in mind beforehand while using the Jointpoint regression model to calculate the trends of certain cancer occurrence?

01 February 2015 2,510 0 View

How can I determine the caliper in a propensity score matching?

A caliper which means the maximum tolerated difference between matched subjects in a "non-perfect" matching intention is frequently set at 0.2 standard deviation as the default such as used in the...

31 December 2014 9,097 4 View

Which type of cancer or solid tumors are strongly associated with CTLA4 aberration causing a state of self-tolerance?

Cytotoxic T-cell antigen-4 gene variants in cancer.

10 November 2014 3,354 3 View

When there are two editors-in-chief, how shall one address them in the Cover Letter?

Shall we just pick one of them to address to? This will not be polite enough, right? But how to write a letter to two persons? Pardon me for this naive question, please.

09 October 2014 8,623 4 View

How to calculate the synergy Index when the measure of risk is hazard ratio?

SAB=(RRAB - 1)/(RRA + RRB - 2)

07 August 2014 9,599 4 View

Is it possible or helpful to establish a ResearchGate Repository collecting all the uploaded full-text articles?

Full-text articles uploaded by ResearchGate researchers are valuable. A repository of these articles can provide better utilization, more efficiently shared amongst us, when the repository...

06 July 2014 9,463 0 View

Can we score (quantitatively evaluate) an observational cohort study using the STROBE checklist?

06 July 2014 5,397 6 View

Which bio-statistical software is particularly good for propensity score matching?

In an administrative database research using retrospective cohort study design, the propensity score matching may be adopted to ensure group A and group B in the cohort will look similar...

05 June 2014 4,867 10 View

Is there any test to determine the cardiovascular risk of patients with obesity? from the perspective of obesity?

We found tests to determine cardiovascular risk taking into account lipid profile, blood pressure, age, history of diabetes, other laboratories. But when weight is involved, there is a paradox. I...

02 March 2021 6,036 1 View

What SPSS analysis should I run with one IV (with two levels) and two DVs?

Hi, I am trying to figure out which test would be most appropriate to run for the following question: Is there a difference in task blood pressure between smokers and non-smokers? There are two...

01 March 2021 8,235 2 View

Issues with Permeabilization during Flow Cytometry?

Hello Everyone. Currently I am working to characterize macrophages in the myocardium after ischemia-reperfusion injury in rats. Due to the low total cell number isolated from rat hearts I can...

01 March 2021 3,867 3 View

What could be some reasons why unstimulated monocytes are getting activated?

Im doing PBMC isolation -> CD14+ enrichment using magnetic beads -> stimulation setup. My negative control is just cells in cRPMI but they seem to get activated over and over again.

28 February 2021 7,883 3 View

Reagents for histology slides?

Dear all, I am planning to study histology and want to do that at home. I have only stained a blood smear with Giemsa but now want to try a wider range of animal tissues. What reagents will I...

24 February 2021 5,430 3 View

Can MicroRNA cross the blood brain barrier?

In diseased conditions, many genes and gene products are visible in the bloodstream. So my question is whether we can find traces of microRNA which is involved in disease and disorder in blood serum?

24 February 2021 7,064 3 View

Is it efficient to do liquid biopsy to investigate the gene expressions of the tumor?

To do liquid biopsy and look for specific gene expressions there are so many published papers. Thera are different protocols and procedures used to isolate circulating cell free RNA or mRNA from...

23 February 2021 7,326 5 View

Is it possible that Cancer cells could survive in heparinized blood for 48 hours?

Hi everyone, I am just wondering if we incubated 200 microliter of whole blood with 50 microliter of cancer cells(1bout 5000cells) do you think that cancer would survive for 48 hours?

23 February 2021 3,840 3 View

Are there any open-source datasets containing physiological information about exercises to be used for an OR-model?

I have just recently started a new "weekend project" in addition to my master's studies and I am looking for a data-set. I would like to use some Operations Research to design an optimal gym...

22 February 2021 8,023 1 View

What is the proper in vitro culturing method to get information about the activation of innate immune cells by VLPs?

Dear All, I am interested in studying the response of immune cells against virus-like particles (VLPs). I used the PBMC in vitro assay and treat it with the VLP using PHA as a positive ctrl while...

16 February 2021 1,337 2 View