How to calculate the synergy Index when the measure of risk is hazard ratio?

More Victor C. Kok's questions See All

Is there any (validated or not yet) evaluation form available for formally assessing the causal relationship in a treatment-emergent mortality?

Is there any (validated or not yet) evaluation form available for formally assessing the causal relationship between a complex treatment and a subsequent treatment-emergent (or hopefully not)...

05 June 2018 7,703 0 View

Circulating tumor DNA (ctDNA) has a very short half-life in peripheral blood, approximately 1.5 to 2 hours only. How will the ctDNA disappear?

According to the previous decent studies, the half-life of ctDNA has been determined to be less than 2 hours. What are the physiological mechanisms to clean-up these ctDNAs in one's peripheral blood?

11 December 2016 9,015 6 View

Why EMBASE literature database is such unfriendly and not accessible?

I'm so frustrated in accessing EMBASE for scientific research. High expense and poor accessiblity. I don't know how and why the EMBASE leads me into this negative impression?

08 September 2015 7,658 0 View

Any caveats that should be kept in mind beforehand while using the Jointpoint regression model to calculate the trends of certain cancer occurrence?

01 February 2015 2,655 0 View

How can I determine the caliper in a propensity score matching?

A caliper which means the maximum tolerated difference between matched subjects in a "non-perfect" matching intention is frequently set at 0.2 standard deviation as the default such as used in the...

31 December 2014 9,251 4 View

Which type of cancer or solid tumors are strongly associated with CTLA4 aberration causing a state of self-tolerance?

Cytotoxic T-cell antigen-4 gene variants in cancer.

10 November 2014 3,549 3 View

When there are two editors-in-chief, how shall one address them in the Cover Letter?

Shall we just pick one of them to address to? This will not be polite enough, right? But how to write a letter to two persons? Pardon me for this naive question, please.

09 October 2014 8,775 4 View

Is it possible or helpful to establish a ResearchGate Repository collecting all the uploaded full-text articles?

Full-text articles uploaded by ResearchGate researchers are valuable. A repository of these articles can provide better utilization, more efficiently shared amongst us, when the repository...

06 July 2014 9,614 0 View

Can we score (quantitatively evaluate) an observational cohort study using the STROBE checklist?

The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)statement: guidelines for reporting observational studies.

06 July 2014 5,579 6 View

Which bio-statistical software is particularly good for propensity score matching?

In an administrative database research using retrospective cohort study design, the propensity score matching may be adopted to ensure group A and group B in the cohort will look similar...

05 June 2014 5,044 10 View

E-commerce businesses, COVID-19 and Entrepreneurial Strategies (innovation, proactiveness and risk-taking)?

Hello: I am looking for articles that address e-commerce businesses and COVID-19 survivors, as well as Entrepreneurial strategies that reflect e-commerce businesses. Blessings Evelyn Dempsey

05 August 2024 5,332 3 View

How to do pca analysis of c-alpha atom of the protein?

i m interested in pca analysis of c-alpha atoms in gromacs for that i used the following gmx_mpi covar -s mdca.tpr -f mdca.xtc -o eigenvalca.xvg -v eigenvecca.trr -av average.pdb -n index.ndx but...

30 July 2024 1,607 1 View

How to calculate FIC index?

Can someone explain to me how was the MIC of MO in combination and MIC of antibiotic in combination was calculated? as shown in the attached file below.

26 July 2024 2,702 1 View

How to identify wetland area in Landsat imagery?

The indexes NDWI and MNDWI are use to identify waterbody. Can I use these index to identify wetland also? Thank you for advance.

25 July 2024 6,242 2 View

Do anyone knows any book dealing with fish growth/zootechnical performances and somatic indexes in aquaculture?

In the aquaculture and fish nutrition research field, a number of growth and somatic indexes are often used, including specific growth rate (SGR), feed conversion rate (FCR), protein efficiency...

22 July 2024 2,480 4 View

Abaqus cylinder buckling riks analysis?

hi, I am doing a risk analysis of a cylindrical fuselage with windows. I have applied contact interactions between the different parts, and I have applied a unit value load to a reference point,...

20 July 2024 647 2 View

Which are the Scopus Indexed Journals in Computer Science with short review time?

Hello, I am looking out for Scopus Indexed Journals in Computer Science with short review time and short time to publish after acceptance (with / without APC). Please mention the journals that you...

19 July 2024 4,250 2 View

How to get Scopus Author Index ??

18 July 2024 4,080 3 View

What kind of t-test can I use if I have two variables measured using the same raw data?

I plan to perform a t-test between risk index and leakage values to know if there is a significant difference between leakage values of low, medium, and high risk pipes. However, the data I have...

10 July 2024 6,199 3 View

What are some Scopus indexed rapid publishing journals in social sciences and humanities? especially having 12 issues per year?

06 July 2024 5,665 0 View

Joseph L Alvarez

The synergy index may be calculated using relative risk (RR), odds ratios (OR), or hazard ratios (HR) in the formula your formula.

Victor C. Kok

Hi, good day, Prof. Alvarez,

Many thanks for your eagerly awaited answer. By the way, could you be so kind to tell us how to calculate the 95% confidence interval of the SAB?

Use the SAB equation to propagate the error using the usual propagation formulae. A reasonable 95% interval is possible if the all values are normally distributed. It may be necessary to propagate with Monte Carlo simulation.

Thank you very much!