Shall we just pick one of them to address to? This will not be polite enough, right? But how to write a letter to two persons? Pardon me for this naive question, please.
Actually, that's a pretty good question! You could address it to both, assuming they're at the same address. Or you could pick the one who seems more likely to be in charge of your paper, if they have clearly different backgrounds. If they're at different addresses, you basically have to pick one - but you can always "CC" the other one.