25 December 2017 3 8K Report

hi everyone,

I have two questions-

1. Can we knock out the mouse gene in both cell- and tissue- specific manner?

2. If so, can we further get the mice whose CD4+ cells in spleen only are lack of the gene? Is this impossible due to the migration of wild-type CD4+ cells into spleen? Or aforementioned migration will never happen though the T cells will migrate out of secondary lymphoid organs once differentiated sufficiently.

Thanks, and any comments are welcome and appreciated.

Jiyuan

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