Leishmania GP63 has been on of the prime proteolytic virulence factor that is known to targets a wide range of substrates that include several phosphatases that are crucial in MAPK signalling and ultimately playing a role in inflammation and immune response. Given the importance of this protein in host modulation, can we have a high through put method to predict the host targets?
The reports show GP63 protease recognizes a consensus site in its target substrates,
P1↓P′1-P′2-P′3, where the arrow represents the site of cleavage. P1 corresponds preferentially to a polar amino acid, P′1 to a hydrophobic amino acid residue, and P′2 and P′3 to basic residues; however, substrate hydrolysis is not restricted to these residues.
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