Hi Parth

Sounds difficult, I don't know whether metall ions are traceable anyway...you would have to exactly disrupt every part of the particle, Ionize it and make it fly in the spray....so maybe you create no mass detection or a wild bunch of values, multipiers of the basic Silver MW that you cannot route to a final mass. You will need to root it to some kind of standard but how would you interpretate that?

For usage, the pure weight of the applied nanoparticle is enough, for a mass distribution you could talk to advanced polymer researchers, maybe an FFF (Field Flux Fractioning) might offer you a usefull chance.

I think in your case, a structural information has much more value than a not validable mass information, so maybe a more complex IR like the catalyst research performs or a an xRay or a advanced coupling of two methods like the material sciences are already using.

As you are using particles, you can try a FACS-Cellsorter, it will give you a distribution of a laserscan ...Fluorescence against particle size of your undestroyed product so you can observe changes in the particle distribution easy and precise.

Hi Parth,

I don't know if MS will work. Unless mass is really necessary I would recommend simply determining the size of the particles using DLS, SEM, or HPLC. DLS (dynamic light scattering) would not destroy the sample. SEM (scanning electron microscopy) is a very common method for determining particle size and shape, but destroys the sample. SEC (size exclusion chromatography) is also a possibility though you would have to have some similar particles of known sizes to compare it to. If a mass is really necessary you might be able to calculate the mass theoretically using the size (if you have some idea of the density).

Thanks frank i too have the same thought regarding the mass spec of nanoparticle

Thanks Morgan for the valuable information regarding other characterization of nanoparticle . Actually I have already done DLS and SEM and mass is not necessary for my knowledge. I just want to confirm it whether it ll work or not

thanks Morgan and parth said 100% right , if go to Maldi some what confirm.