Can someone explain level (low/normal/high) of tankyrase1 (PARP5a) expression in normal and cancer cells?

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Jie Li

Both in MCF10A and MCF7, its expression level was low. And it is lower in MCF7.

Alex George

Thank you Li ! so tankyrase1 activity is lower in cancer cell lines.? do u have any other experience or literature to explain this phenomena?

Sorry I knew a little about this field.

Anita Tripathi

You can go through a paper

" CHEMICAL INHIBITOR FOR TANKYRASE 1 TO CONTROL CELL PROLIFERATION IN CANCER "

In this paper you will definitely find some thing beneficial or some related reference Papers.