Can Protein kinase A (PKA) be activated independent of cAMP?

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Sandra Annisa

I have results from my experiments showing that PKA is activated despite no production of cAMP and was looking for possible explanations.

Guillermo Romero

I know of two examples, but I am not a PKA expert.

One is by free radicals: http://www.ncbi.nlm.nih.gov/pubmed/20083118

The second is by sphingosine: http://www.jbc.org/content/280/28/26011.long

Neil A Bradbury

Guillermo is correct; however I would also ask on what basis you assert that there is no production of cAMP?