Dear Researchers,
Its well known that miRs after their complete biogenesis are released into the cytoplasm and they involve in different functions. I do have read from literature that certain miR family members interact among themselves. Do they interact with other miRs after or before they are completely processed by their respective biogenesis? And how can this be evaluated?
I would be glad to get some help from you on the above question.
Thanks in advance.
Could you post a reference to the statement "interact among themselves"? Does that reference give you a clue about which mechanism they are talking?
Its on the whole, cytoplasmic interactions and others if any. I am actually new to this field and will be glad to get some help from you people. Sorry for delayed response
From the publications you sent me:
https://www.researchgate.net/publication/277477657_Identification_of_lung_cancer_miRNA-miRNA_co-regulation_networks_through_a_progressive_data_refining_approach
talks about co-regulated miRNAs, which probably means that there is another factor (e.g. transcription factor) that regulates groups of them in the same way.
https://www.researchgate.net/publication/261258466_Integrative_analysis_of_miRNA-mRNA_and_miRNA-miRNA_interactions
indeed uses the wording "Interacting miRNAs" but they do that in the sense of network relation, not physical biological interactions. From your question it sounded like you were interested in the latter.
I do not know about any evidence for direct interaction between mature miRNAs coming from different loci. I can imagine that a miRNA could negatively regulate the host transcript for another miRNA and result in there expression level being reverse correlated. With the positive correlation between miRNAs you should most likely assume a third actor's fault - e.g. transcription factor.
Article Identification of lung cancer miRNA-miRNA co-regulation netw...
Article Integrative analysis of miRNA-mRNA and miRNA-miRNA interactions
Dear Katarzyna Hooks,
Thank you very much for responding. I'm interested in finding out both physical and network interactions between miRs. And, I could get only such type of papers for reference.
I will be glad to get any articles regarding this. Thanks in advance
Hello Snehaa,
I agree with Katarzyna.
However, would like to add that certain exogenous miRNAs can also interact with native miRNAs. We recently published an article based on this hypothesis.
https://www.researchgate.net/publication/301578307_Are_We_Eating_Our_Way_to_Prostate_Cancer-A_Hypothesis_Based_on_the_Evolution_Bioaccumulation_and_Interspecific_Transfer_of_miR-150
I am very sure you will enjoy this article too.
Warm regards,
Venk
Article Are We Eating Our Way to Prostate Cancer—A Hypothesis Based ...
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