The common symptoms of diabetic type 2 patients are numbness, disesthesias, vision blur. What are the mechanisms behind these? Can it be related to obesity?
Hi Sneha,
Potentially important mechanisms associated with type 2 diabetes and insulin resistance include:
1) Increased breakdown of lipids within fat cells.
2) Resistance to and lack of incretin, high glucagon levels in the blood.
3) Increased retention of salt and water by the kidneys, and inappropriate regulation of metabolism by the system.
However, not all people with insulin resistance develop diabetes, since an impairment of insulin secretion by pancreatic beta cells is also required.
Type 2 diabetes is basically due to insufficient insulin production from beta cells in the setting of insulin resistance, which is the inability of cells to respond adequately to normal levels of insulin occurring primarily within the muscles, liver, and fat tissue.
In the liver, insulin normally suppresses glucose release. However, in the setting of insulin resistance, the liver inappropriately releases glucose into the blood.
The proportion of insulin resistance versus beta cell dysfunction differs among individuals, with some having primarily insulin resistance and only a minor defect in insulin secretion and others with slight insulin resistance and primarily a lack of insulin secretion.
These are the key points that you have to know about Type 2 Diabetes mellitus...
Find the attachment too... i hope you may find the answer for your question through this paper
Thank you...All the best
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