Polyvinyl alcohol (PVA) can be used to enhance the solubility of poorly soluble drugs for intravenous administration. While specific concentration limits can vary, studies suggest that concentrations around 10-20% may be effective, but it is crucial to conduct stability and safety assessments for your specific formulation.

Polyvinyl alcohol (PVA) can be used as a solubilizing agent for poorly soluble drugs in certain formulations, including intravenous (IV) formulations. However, its use in IV formulations depends on several factors, such as the specific drug, the required solubility, and the compatibility of PVA with the body.

Key Considerations:

In conclusion, PVA can be used for drug solubilization in IV formulations, but careful optimization of concentration and safety testing is required. The typical range would be 1%-10% PVA, depending on the drug and formulation specifics. Always consult with a formulation expert or pharmacologist to ensure the suitability of PVA for your specific drug and formulation.

Here, it’s fine to use PVA to dissolve your drug. The concentration is usually between 0.5%-5%, but starting with 1%-3% is a good idea. To dissolve it, you’ll need to heat the solution to 60-90°C, and it’ll form a uniform solution once it cools down. If it doesn’t dissolve well, you can try adding a bit of ethanol or DMSO, or even use ultrasound to help. Just make sure PVA is compatible with your compound and doesn’t cause any toxicity or side effects. Overall, PVA works, but you’ll need to tweak the concentration and method based on your experiment.