Atropine is an antagonist of the muscarinic acetylcholine receptors located in end organs (e.g. heart) as well as in brain. While acetylcholine is released from the vagal efferent fibers, glutamate is the primary neurotransmitter for vagal afferent signaling to the nucleus of the solitary tract. Is there any evidence if atropine can also block vagal afferent signaling?
In my opinion, as typically the colinergic neuromodulation is negative (i.e., mediated by m2 and m4), in any case, atropine should facilitate afferent transmission rather than block it. However, I have never read about effects of atropine on afferent transmission. So, I am curious now. Let me know what you find :)
Article Inhibitory effects of various spasmolytics on the vagal affe...
https://www.europeanurology.com/article/S0302-2838(09)01326-8/fulltext
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