How are you defining your problem? I mean, what are your criteria to determine if a peptide is toxic somehow? Sometimes, if you broke down your problem in more manageable pieces, you can use the tools that you know to do the job.

Hi,

I think you should go through by this paper.

http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0073957

The app from this paper is located at: http://www.imtech.res.in/raghava/toxinpred/multi_submit.php

this may be helpful to you if you work in peptide based therapeutics

SATPdb: A database of structurally annotated therapeutic peptides.

http://crdd.osdd.net/raghava/satpdb/

paper link

http://nar.oxfordjournals.org/content/early/2015/11/01/nar.gkv1114.full