0.1M-HCl to crystallise the hydrochloride salt is a possibility.

Hi sir, Good morning and Thank you very much for your suggestion , I am also thinking in same way but I have not tried that and I got some confidence from your reply , defiantly I will try this one .

Thanking you

regards

vijay

Hi sir , I tried with HCl in IPA (6M) around 1 eq. compound I dissolved in DCM/Ethyl acetate (compound purity ~70%) . I tried at RT and at 0 C. its not crystallized out,

Do u think methyl ester will hydrolyze in presence of moisture with HCl ?

actone solvent with 6 hrs stirring and cool to 0ºC.

i worked on this L-serine derivatives.

Hi sir (Peter Sharratt ), I tried with HCl in IPA (6M) around 1 eq. compound I dissolved in DCM/Ethyl acetate (compound purity ~70%) . I tried at RT and at 0 C. its not crystallized out,

Do u think methyl ester will hydrolyze in presence of moisture with HCl ?

Hi Jagan, thank you very much for your reply , I will try your suggetion

regards

vijay

Hi vijay,u r hydroxy also protected? Tell me the protected group.