Can anyone recommend a software that is suitable for a nonlinear polynomial regression and splines or example on how to use it?

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Anton N. Gvozdetsky

Hello Emmanuel Nuamah

https://bookdown.org/alecri/thesis/4-methods.html and https://cran.r-project.org/web/packages/dosresmeta/vignettes/dosresmeta.pdf

Article Meta-Analysis For Linear and Nonlinear Dose-Response Relatio...

https://doseresponse.github.io/medrc/index.html

Emmanuel Nuamah

Thank you very mich Anton. I will check it out.

Koen Van de Moortel

You can use this:

www.lerenisplezant.be/fitting.htm

but polynomial regression is very dangerous to use since it doesn't explain anything and it can never be extrapolated.