Where can I find the spike protein amino acid sequence of SARS COV-2 variant B.1.1.7?

I need the spike protein amino acid sequence of SARS COV-2 variant B.1.1.7 (also named as VUI 202012/1)

29 December 2020 2,409 3 View

Is it possible to carry out Path analysis with multiple variables without doing the CFA for all those variables together?

HI. I am trying to develop a model to see how some factors from three domain of resources- Social, Cognitive, Non-cognitive affects the peoples CP. I have many such latent factors from each of the...

03 October 2020 2,610 3 View

Name the journals having highest impact factors in science and pharmaceutical science?

What is the name of the journal in science having highest impact factor? and What is the name of the journal having highest impact factor in pharmaceutical sciences?

03 June 2020 7,054 6 View

How much is the EELS plasmon peak reliable for calculating Fermi energy level for alloys and compounds?

In general the low loss electron energy loss peak contain the information about the electronic structure of materials. From free electron model (Drude Model) the plasmon energy is given by a...

26 May 2020 6,315 3 View

A vaccine effective in monkey against corona virus can be 100% effective in human?

An experimental COVID-19 vaccine protected monkeys from pneumonia and prompted a strong immune response in the animals. Vincent Munster at the National Institute of Allergy and Infectious...

15 May 2020 7,939 6 View

What is the difference between drug loading and Entrapmet Efficiency of drug?

During characterization of Nano-particles, i often get confused between these two terms. Please suggest.

23 April 2020 5,178 1 View

Zeta potential of nanoparticles apart from polymers depends on which factors?

Basically i prepared PLGA based nanoparticles by QbD approach. As Zeta potential is a Critical Quality Attributes(CQA) i have to explain the effect of CMAs and CPPs on CQA. Due to PLGA polymer,...

15 April 2020 5,035 5 View

How far can we modify a standardize test tool for adaption ?

I would like to know that if i want to use some pre standardize test tool for assessment say for assessing intrinsic motivation and i have a standardize inventory that assess Motivation, with...

21 January 2020 1,248 3 View

Do we always need to have error degree of freedom greater than 12 to start our research ?

I have attended different universities during my study programme and for different conference and seminars, where I notice a critical number always suggested by almost every scientist/professors...

03 December 2019 420 3 View

Climate change is real. Is it really going to have some significant negative impacts on agricultural output ?

Climate change is real and over the years the weather parameters are changing, so the global hydrological cycle, atmospheric circulation, bio-geochemical cycles also changing. But to some extent...

25 November 2019 9,336 8 View

Can we classify HV and LV lines based on line length?

I have dataset which shows the length of power lines. I need to classify the lines based on the line length. Is there a rule to classify the High voltage (HV) and low voltage (LV) lines based on...

03 March 2021 4,116 4 View

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02 March 2021 3,060 3 View

Does Napabucasin soluble in dichloromethane and in ethanol?

I need to prepare a solution of Napabucasin (inhibitor of cancer cell stemness) in dichloromethane. The drug is expensive, so maybe somebody already tried to do it. If it is soluble, what is the...

02 March 2021 9,945 3 View

Issues with Permeabilization during Flow Cytometry?

Hello Everyone. Currently I am working to characterize macrophages in the myocardium after ischemia-reperfusion injury in rats. Due to the low total cell number isolated from rat hearts I can...

01 March 2021 3,867 3 View

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

Could you please recommend some good journal that accept very long revie papers (approximately 6000+ words) in neurosurgery, cancer biology ?

01 March 2021 8,087 3 View

Which cell line should we use to perform biological dosimetry experiments?

We are preparing some experiments based on irradiating cells under different conditions in order to evaluate the effects in terms of DNA damage, genetic expression, etc. As our project is...

01 March 2021 3,355 3 View

Is it possible for two human neuronal cell lines to have different gene sequence for the same protein?

I am looking at the ATP1A2 (Sodium/Potassium ATPase alpha subunit 2) in two human neuronal cell lines. Expression levels of this protein seems to be almost equal when detected by one antibody....

01 March 2021 3,607 3 View

Is CD44 degraded in lysosome together with hyaluronan after CD44 mediated endocytosis of hyaluronic acid?

Also when RHAMM binds hyaluronic acid, they get internalized, will RHAMM also be degraded? Or both CD44 and RHAMM will be transferred back to the cell membrane? Asking for breast cancer cell line...

01 March 2021 8,169 2 View

Do you need the CMV enhancer before the CMV promotor for a proper function of CMV on the gene that follows?

I'm a student and I have to produce a cell line with a knockin for the NRF2 gene with GFP. I have to put a promotor in front of the GFP because the gene will be too far away from the promotor of...

28 February 2021 7,127 2 View

What could be some reasons why unstimulated monocytes are getting activated?

Im doing PBMC isolation -> CD14+ enrichment using magnetic beads -> stimulation setup. My negative control is just cells in cRPMI but they seem to get activated over and over again.

28 February 2021 7,883 3 View