Hi everyone!

I'm trying to produce a nanocapsule using TCM, Span 80 and Tween 80 (1:2:2 ratio) and PCL (100 mg). However, when I transfer the organic phase to the aqueous phase (interfacial deposition of preformed polymer), the PCL precipitates (no matter the parameters, i.e., temperature, rotation, etc.).

(This apply to the blank nc and the compound nc).

Does anyone have any insights?

Thanks in advance!