Dear Naheed Mojgani

Pls. find the attached files

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1933431/

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000300014

http://opensample.info/tuberculosis-diagnosis-using-immunodominant-secreted-antigens-of-mycobacterium-tuberculosis

http://cvi.asm.org/content/15/12/1788.full

http://aac.asm.org/content/56/4/1735.full

https://www.ncbi.nlm.nih.gov/pubmed/23602700

http://www.sciencedirect.com/science/article/pii/S0140673613601774

http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(04)01206-X/abstract

http://cdn.intechopen.com/pdfs-wm/28547.pdf

http://www.medsci.org/v12p0126.htm

https://www.researchgate.net/profile/Magdalena_Tary-Lehmann/publication/13506559_Enhanced_Responses_to_Mycobacterium_tuberculosis_Antigens_by_Human_Alveolar_Lymphocytes_during_Active_Pulmonary_Tuberculosis/links/0f31753c683d034546000000.pdf

http://medind.nic.in/iae/t02/i4/iaet02i4p225g.pdf

Hoping this will be helpful

Regards

Prof. Houda Kawas

Article Enhanced Responses to Mycobacterium tuberculosis Antigens by...

Thanks a lot

You most welcome

Houda

Dear Naheed,

Ag85B is found in most pathogenic mycobacterial species, including opportunistic pathogens such as M. avium, as well as the BCG vaccine, although expression by BCG seems to be quite low. Ag85B is strongly immunogenic in multiple species, including humans and is included in many different TB vaccines currently under development: in animal models it shows quite good efficacy against bacterial replication.

It has also been tested as a diagnostic antigen, both under its own name and under the alternate name of 32kDa antigen. However, the specificity of the antigen is low, and reactivity mirrors very closely that of the TST. Studies comparing Ag85B with non-infected TST+ controls have repeatedly shown that they cannot reliably seperate the two groups. It has therefore largely been abandoned as a potential diagnostic.

Dear Timothy

This is what I exactly wanted to say

thanks a lot