Dear Prishnee

There is a genetic predisposition to synthesize the excess cholesterol but is less frequent. In the great majority is more frequent the genetic predisposition to produce excess cholesterol.

When only one parent has elevated cholesterol , there is risk of transmitting the genetic load . If the father and mother have the elevation , the chances increase . In cases of marriage between cousins ​​, bias is even greater . The family carries a genetic load and it is very likely that the child will be too.

There are other ways to avoid the increase of cholesterol and even reduce it :

Doing physical exercises : physical activity can help lose weight and reduce tensions . Controlling weight , doing exercise or playing sports , the person feels better and reduces the risk of myocardial infarction and cholesterol levels in the blood

No smoking : cigarette smoking is a risk factor for coronary disease . Allied to cholesterol , multiplies the risks

Avoid stress : a less stressful life also decreases the risk of heart attack and lowering cholesterol . Whenever possible the person should turn your daily activities into something that gives you satisfaction . A diet low in fat and cholesterol levels

Use white meat is preferred; If you eat red meat - lean meat and remove visible fat ; Do not abuse the excessive consumption of egg ; Use regularly and vegetables on the menu - especially soybean containing phytoestrogens and antioxidant

N.B. Cortisol and adrenaline stimulate cholesterol production. It follows that blood cholesterol may increase with a stressful lifestyle. Other factors - genetic, wider lifestyle, diet will also influence.

Thank you gentlemen for your insightful responses. They've been very helpful.

Firstly, seek medical guidance: do the necessary blood test to determine the degree of the sickness,

Then the medical provider would subscribe a chronic medication suitable for the specific patient depending on things such as race, gender, weight.

Adaption of lifestyle as mentioned above would be third.

Regular check ups to see if disease worsen or is under control.

Please read through these articles, great research being done in this field. Hopefully all with good results and prospects.:

http://europepmc.org/articles/PMC1245349/pdf/bmjcred00006-0011.pdf

http://www.nature.com/pr/journal/v35/n2/abs/pr199430a.html

Dear Prishnee, yes, sure, it is possible for someone with genetic risk factor (known as familial hypercholesterolemia, autosomal dominant, prevalence estimation 1:500) which leads to cholesterol excess, and also stress and inflammation can increase risk factor of excess production of cholesterol (endogenous cholesterol). I know for adult Statins should be the initial treatment for all adults with FH. Ezetimibe monotherapy is recommended as an option for the treatment of adults with heterozygous-FH, especially who are intolerant to Statins. Recently gene therapy for FH using ligand facilitated transfer of a liposome:LDL receptor gene complex

Thank you Eugene for your reply and the papers, I'll definitely go through. Thank you Dr Hedayati for your responses. May I ask a further question? To which other diseases that person might be more prone to other than cardiovascular disease, if he or she doesn't take precautions?

You're welcome dear Prishnee, yes of course. I think cardiovascular is end stage of a group of diseases and start of new disease. Inflammatory diseases are the first stage, cardiovascular diseases start with micro-inflammation and continue with inflammation.

Thank you very much again for shedding light on this topic. :)

Beyond doubt there is a genetic predisposition to the excess cholesterol in the body, however to control this problem there are various factors but chiefly its a wise selection of diet,regular exercises,healthy lifestyle.

There is a tendency in the modern age to eat a lot and frequent partying which results in very unhealthy eating habits and also to load the system with empty calories mainly carbonated drinks, this results not only in sedentary lifestyles and also in obesity.

Stress is a very common factor in the modern life and its unavoidable, so to relieve stress one has to have a disciplined lifestyle with either systematic physical exercises clubbed with a decent time spent on spiritual routines and as well as as meditation.

I full agree with Nelson Elias, about diet, physical exercise, lifestyle and genetics. But I think genetics and stress are the most important factors, but you can deal with, doing all these good things he proposes (for genetic load, obviously you cannot do nothing, well yes, take anticholesterol medicines, if other measures doesn't help). Stress it is perhaps the most difficult due to unhealthy lifestyles.

Just two points, if someone have thyroid problems untreated, levels of cholesterol are correlated with high and low thyroid (low thyroid, raises cholesterol levels, and high thyroid, the contrary). A detail about diet, eggs: you can take only the white part of the egg, albuminam, and not the yellow one (plenty of cholesterol)

‘Familial hypercholesterolemia is an inherited condition that causes high levels of LDL (low density lipoprotein) cholesterol levels beginning at birth, and heart attacks at an early age. It is an autosomal dominant inherited condition where a parent who carries an altered gene that causes the condition has a 1 in 2 (50 percent) chance to pass on that altered gene to each of his or her children. The altered gene (gene mutation) that causes familial hypercholesterolemia is located on chromosome number 19.’

Treatment is to lose weight by exercise and low fat diet and to use cholesterol lowering drugs like Statins. Individuals who have homozygous Familial hypercholesterolemia may require periodical LDL apheresis.

Ref:

Learning About Familial Hypercholesterolemia, https://www.genome.gov/25520184

Other features of Familial hypercholesterolemia apart from heart disease are •Xanthomas (waxy deposits of cholesterol in the skin or tendons).

•Xanthelasmas (cholesterol deposits in the eyelids).

•Corneal arcus

Familial hypercholesterolemia is due to a lack of LDL-receptors. This was shown by Goldstein and Brown who received the Nobel price for their work demonstrating this. High cholesterol caused by other conditions was called "polygenetic" by the same authors in their textbook chapter in Harrisons Principles of Internal Medicine.

Nevertheless, cholesterol level has nothing to do with the risk of dying from cardiovascular disease. The 30-year follow-up from Framingham showed that.there was no correlation http://www.ncbi.nlm.nih.gov/pubmed/3560398. However, later published results from the same study showed that the incidence of coronary disease did indeed correlate to LDL and total cholesterol http://www.ncbi.nlm.nih.gov/pubmed/2523187.

This I call the Framingham paradox. How can the incidence of a deadly disease increase with high cholesterol, but not the mortality? There is an obvious reason. Lack of blinding. The same is true with the statin studies. Statins reduces the number of cardiovascular incidents to larger degree than mortality. Actually in studies with only primary prevention, statins have no effect on mortality, only on incidence. Why? Patients in studies can check there cholesterol elsewhere. And those who found they got placebo -less cholesterol reduction -shouldn't they be more prone to seek hospital care and get a diagnosis for a minor NSTEMI event? I would.. I recently receided a letter from one of the academic doctors involved in the 4S study. I do not believe in the cholesterol myth any longer, was his statement.

Ralf Sundberg MD PhD Associate professor of transplant surgery, Malmoe Sweden. Author of a book on the myths of modern medicine, soon published in Englisn

it is possible for someone with genetic risk factor (known as familial hypercholesterolemia, which leads to cholesterol excess, and also stress and inflammation can increase risk factor of excess production of cholesterol (endogenous cholesterol).Such pts. should have family screening and early statin therapy for whole life.

Atif Hayat

Isra university Hyderabad.

Actually statin therapy does not prolong life. http://bmjopen.bmj.com/content/5/9/e007118.long .It may reduce the number of so-called cardiovascular events in randomized trials, but it has to be kept in mind that this measure is subject to bias, because neither study objects nor doctors that treat them can be blinded to cholesterol levels