I want to study the effect of artificial sweeteners in the diabetic rat model. The diabetic rat model is induced by giving high fat diet for 2 months. After making the rat diabetic (type II) , I want to keep those animals for 90 days to treat with the overdose of artificial sweetener. Is there possibility of survival of these animals till 90 days in my toxicity studies.
Hi Arul,
It all depends on the severity of diabetes. The induction of diabetes can be moderate so the animal can survive and also be diabetic. If they are severely diabetic obviously the animal will be undergoing changes each day. Even to withstand your treatment the animal should be stable, may be do a mild moderate and sever diabetes induction with your high fat diet and see the stability of your animal then proceed to treatment. Hope this helps.
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