I want to assess if a bHLH transcription factor (Ascl1) is able to open chromatin (e.g. by interaction with repressor complexes ot HDAC) of a specific target gene to promote the access of another TF. I have not found a lot of information in literature. Can you help me?
This is a paper with information on this subject:
Development. 2013 May 1
Ascl1 reprograms mouse Muller glia into neurogenic retinal progenitors.
Pollak J, Wilken MS, Ueki Y, Cox KE, Sullivan JM, Taylor RJ, Levine EM, Reh TA.
http://www.ncbi.nlm.nih.gov/pubmed/23637330
The authors showed that upon Ascl1 lentiviral transduction in Müller glia, the chromatin signatures of Ascl1 targets change from a repressed state to an open one.
I hope this helps!
Tank you Anna I already know this paper, it seems to be the only relevant publication about the topic and it's very interesting.
Maybe some of theses paper can help you:
The bHLH factor deadpan is a direct target of Notch signaling and regulates neuroblast self-renewal in Drosophila.
San-Juán BP1, Baonza A.
The bHLH factors extramacrochaetae and daughterless control cell cycle in Drosophila imaginal discs through the transcriptional regulation of the Cdc25 phosphatase string.
Andrade-Zapata I1, Baonza A1.
The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development.
San Juan BP1, Andrade-Zapata I, Baonza A.
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