Bcl-2 is anti-apoptotic, so you would want to inhibit its function in order to stimulate apoptosis.

BCL2 (among other actions) binds to and inactivates BAX and other pro-apoptotic proteins, and thereby inhibiting apoptosis

Article Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways...

Hello Ruby Khin

Bcl-2 is an apoptosis suppressor gene. When Bcl-2 is overexpressed in cancer cells, it may inhibit the pro-apoptotic signals, allowing the cancer cell to survive under stressful conditions. Overexpression of this protein in cancer cells may block or delay the onset of apoptosis. So, bcl-2 inhibition would be the right approach. Bcl-2 inhibitor will bind to and inhibit the activity of Bcl-2 restoring apoptotic processes in tumor cells.

Best.

The Bcl-2 family of proteins consists of about 25 pro- and anti-apoptotic members, which interact to strike a balance between newly forming cells and old dying cells. Targeting the anti-apoptotic Bcl-2 family of proteins can improve apoptosis and thus can be a target for cancer chemotherapy.

1. Article Mechanisms of Action of Bcl-2 Family Proteins

2. Article Mechanisms of Action of Bcl-2 Family Proteins

3. https://www.nature.com/articles/cdd2017183

4. https://www.hindawi.com/journals/ah/2012/524308/