I am investigating the role of histone modification during hippocampal memory formation. It is the best if I could perform contextual fear conditioning on mice. However, we unfortunately do not have equipment for this.
We have following equipments/apparatus on site;
- open field
- radial arm maze
- y/t maze
- morris water maze
Is there any behavioural test that could substitute fear conditioning test? (with limited equipments seen above or potentially we can purchase if settings are less expensive.)
It'll be also very helpful if you could suggest me any articles.
Kind regards,
Yuka
Hi Yuka,
There is no substitute for contextual fear conditioning if you want to investigate contextual fear conditioning... but if you want to focus on hippocampus-dependent memory (not necessarily *fear*), you can use the water maze for spatial tasks.
Article Hippocampal CA3-region is crucial for acquisition and memory...
Article Effects of Hippocampal Histone Acetylation and HDAC Inhibiti...
https://www.nature.com/articles/nprot.2006.116
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