Endogenous Mitochondrial Apoptotic Pathway Rotenone (HY-B1756) Exogenous Death Receptor Pathway Quercetin (HY-18085) The p53 apoptotic pathway is unique, with literature indicating that p53 can induce cell cycle arrest and apoptosis through different pathways. Research on p53 inhibition primarily focuses on small molecule inhibitors (such as PFT-α) and RNA interference technology. PFT-α (HY-15484) is a small molecule inhibitor capable of specifically inhibiting p53 activity. By binding to p53, it blocks its transcriptional activation function, thereby reducing p53-dependent apoptosis. In multiple cell models, PFT-α has been shown to decrease cell death induced by chemotherapeutic drugs. Additionally, small interfering RNA (siRNA) (HY-RS16297) or antisense oligonucleotides (ASO) can be used to specifically reduce p53 expression, thereby inhibiting its apoptosis-mediated effects.The answer to this question is provided by MedChemExpress Technical Support.

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P35, a tumor suppressor protein discovered in 1993 and declared the "molecule of the year," regulates many cellular functions, including metabolism, signal transduction, apoptosis, etc. Mutant forms of this protein are associated with the development of many tumours. So, many inhibitors are being experimented on, and some are in clinical trials, either to prevent their degradation or to block the metabolic effects of their mutants, as Qui has highlighted above.

Please, familiarize yourselves with Apoptosis of cellular mechanism in norm and pathology In the my entitled "Biophysical and Biochemical Mechanisms of Organism Development in norm and pathology" of the Chapter 2, Part 2.1.10. The Role of Mitochondrial and Nuclear Functions in Maintaining the Stability of the Internal Energy and Internal mMedium in an Organism and its Cells. and Part 2.1.11. Supplemental Mechanisms for Maintaining the Stability of an organism's Internal Energy.