Just wondering about their expense to make. Does liquid propulsion cause excess interference in IR?. A multifunctional HPLC that checks for impurities would be more valuable. Does the liquid sample need to be stationary to be ananlytes by IR?.
Hi Mel, I know that Germanium discs are used for IR analysis of polymers which has been separated by SEC. Maybe the following articles will helpful to you:
http://www.sciencedirect.com/science/article/pii/S0021967399007785#aep-section-id17
http://www.pss-polymer.com/uploads/tx_pss/pdf/publication/Pasch-NewDevelopmentsinMultidimensionaChromlMacroRapidComm2005.pdf
Greetings Markus
Most HPLC's come equipped with a UV detector (PDA/DAD). An IR detector is known but not typically used since everything absorbs (thus molecular spectroscopy) including mobile phase solvents like Methanol, Water....
Yes and in hplc you cannot run a blank using one cuvette the mobile phase is constant and organic.
True. But these peaks can 'swamp' out' any peak of interest. An example is the very broad water peak at 3300 cm-1. Water is always a component of a 'reverse phase' mobile phase
Flow through cells are cheap. There are selected bands in the IR that are not swamped out by conventional eluants; depending on what you're looking for it could be useful.
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