Phopshodiesterse 3A and 9A inhibitors are specifically regulating oocyte physiology reversibly and have potential to be used as nonhormonal, reversible therapeutic drugs for ovarian functions.
Our long standing understanding for mammalian ovary is that it has fixed number of germ cells and duty of the ovary is to ovulate high quality ovum for successful fertilization and early embryonic...
11 October 2021 957 8 View
As we know that the sperms function test is widely used for the management of male factor issues worldwide. However, similar parallel test is not available for the management of egg factor issue...
08 October 2021 4,336 2 View
Recent evidences suggest that mitochondria play important roles in determining the quality and fate of the oocytes in several mammalian species. Changes in shape, number as well as the...
05 October 2021 4,617 4 View
The maturation promoting factor (MPF) is a key regulator of cell cycle that has regulatory subunit (Cyclins) and catalytic subunit (Cdks). Dissociation and degradation of specific cyclin...
29 September 2021 3,902 5 View
There are many geophysical and remote sensing methods to determine the crustal deformation and active tectonic movements. I need some research papers related to active tectonic movements in...
19 January 2021 2,559 3 View
The Canadian Institute of Mass Communication (CIMCweb.com) is embarking on a pilot project to create language-barrier-free learning environment for deaf students, as a scalable model for...
28 July 2020 9,242 1 View
Type of insult (drugs, oxidants, intoxicants and other factors) and duration of exposure have been studies well to analyze the initiation of various death pathways (apoptosis, necrosis,...
13 June 2020 6,836 1 View
Several studies indicate the presence of oogonial stem cells (OSCs) in postnatal mammalian ovaries. It has long been held that the ovaries contain a fixed number germ cells that remains...
05 June 2020 469 0 View
There are several pathogenic viruses but the way corona became pendemic remains mystry. Is it natural and came from animal origin or artificialy made so in the lab? Its spreading ability and...
18 May 2020 2,566 0 View
Veriety of insult including stress initiate various death pathways in specific manner. It remains unclear whether specific type and its level decides which death pathway including PCD would be...
03 May 2020 3,672 0 View
I am experimenting with cancer and non-cancer cells in a 12-well plate for 4 days with a seeding density 1*10^4/well, however, I noticed that the control group growth rate slows down on D3. Should...
07 August 2024 2,283 2 View
I work on MCF7 cell cell for anticaner purpose and I wa to do drug preperation the drug ( secondary metabolites extracted from Aspergillus) My question which solvent is better with these secodary...
03 August 2024 4,725 2 View
Hello, if you made a transwell assay where you incubate the cells with a nanoparticle-encapsulated drug and considering that in the oposite compartment you'll have both the free and encapsulte...
03 August 2024 2,730 1 View
How do soil microbes affect plant health and productivity and how do plants interact with soil microorganisms and contribute to soil fertility?
31 July 2024 5,087 4 View
How do pollutants in soil affect soil microorganisms and role do microorganisms play in nutrient cycling and soil fertility?
31 July 2024 368 2 View
What is the role of microorganisms in soil fertility and crop production cycles and role of microorganisms in mineral transformation?
31 July 2024 8,483 8 View
I am currently working on a project that involves extracting cell membranes, for which we disrupt the cells using sonication. During the initial extraction process, we add protease inhibitors to...
30 July 2024 7,077 1 View
I am working in the filed of long acting drugs with Nano formulation. I want to study the efficacy of my formulation in 2D cell cultures while this required media change on every two days. In such...
24 July 2024 8,696 0 View
Hello, I am searching for the binding position of a drug in a ribosome, based on previous work indicating it binds there. The resolution of the ribosome-drug Cryo-EM map is around 2.5 Å. I've been...
19 July 2024 2,155 0 View
How to calculate percentage cumulative drug release when, Total volume of dissolution media = 250ml Added formulation was equivalent to 10mg of drug Sample withdrawn = 1ml each time Sink condition...
15 July 2024 4,192 1 View