Several studies indicate the presence of oogonial stem cells (OSCs) in postnatal mammalian ovaries. It has long been held that the ovaries contain a fixed number germ cells that remains unchanged during a woman’s lifetime. However, recent studies have provided evidence of mitotically active OSCs in adult murine and human ovaries. These OSCs may be a potentially inexhaustible source of oocytes that can be exploited to achieve fertility in women who are infertile or have an exhausted ovarian reserve. It remains unclear whether these OSCs can undergo spontaneous meiotic maturation in vitro similar to those isolated from ovary and cultured in vitro.
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