Does type and level of insult decide initiation of specific death pathway in mammalian cells?

04 May 2020 0 4K Report

Veriety of insult including stress initiate various death pathways in specific manner. It remains unclear whether specific type and its level decides which death pathway including PCD would be initiated.

Badges
Science topic

More Shail K Chaube's questions See All

Does oocyte generated from Oocyte like stem cell/neo-oogenesis/adult oogenesis is as good as natural oocytes?

Our long standing understanding for mammalian ovary is that it has fixed number of germ cells and duty of the ovary is to ovulate high quality ovum for successful fertilization and early embryonic...

11 October 2021 957 8 View

Similar to sperm funtion test, do we have scope to develop a oocyte function test for the management of women's egg factor issues?

As we know that the sperms function test is widely used for the management of male factor issues worldwide. However, similar parallel test is not available for the management of egg factor issue...

08 October 2021 4,336 2 View

Can the shape, number and distribution of mitochondria be used as a biomarker for oocyte quality?

Recent evidences suggest that mitochondria play important roles in determining the quality and fate of the oocytes in several mammalian species. Changes in shape, number as well as the...

05 October 2021 4,617 4 View

Which one is responsible for meiotic resumtion in mammalian oocytes i.e. "maturation promoting factor (MPF) activation or MPF destabilization?

The maturation promoting factor (MPF) is a key regulator of cell cycle that has regulatory subunit (Cyclins) and catalytic subunit (Cdks). Dissociation and degradation of specific cyclin...

29 September 2021 3,902 5 View

Can anyone please suggest the research papers related to Crustal Deformation in Eastern Indian peninsular/Eastern Ghats/East coast of India?

There are many geophysical and remote sensing methods to determine the crustal deformation and active tectonic movements. I need some research papers related to active tectonic movements in...

19 January 2021 2,559 3 View

What are the latest advancements in computer-based SignLanguage Interpretation?

The Canadian Institute of Mass Communication (CIMCweb.com) is embarking on a pilot project to create language-barrier-free learning environment for deaf students, as a scalable model for...

28 July 2020 9,242 1 View

Is there any master switch that decides which death pathway will operate to eliminate a cell in mammalian tissue?

Type of insult (drugs, oxidants, intoxicants and other factors) and duration of exposure have been studies well to analyze the initiation of various death pathways (apoptosis, necrosis,...

13 June 2020 6,836 1 View

Can oocyte like cells generated through neo-oogensis undergo spontanous meiotic maturation in vitro?

Several studies indicate the presence of oogonial stem cells (OSCs) in postnatal mammalian ovaries. It has long been held that the ovaries contain a fixed number germ cells that remains...

05 June 2020 469 0 View

What structural differences enabled corina virus in rapid spread globally?

There are several pathogenic viruses but the way corona became pendemic remains mystry. Is it natural and came from animal origin or artificialy made so in the lab? Its spreading ability and...

18 May 2020 2,566 0 View

Can we determine the fate of germ cells in mammalian ovary prior to ovulation?

Majority of female germ cells are eliminated from cohort of ovary and only few germ cells are culminated in oocyte and then ovum after ovulation.

01 May 2020 268 0 View

What is the role of oxidative stress in toxin-induced carcinogenesis?

What is the role of oxidative stress in toxin-induced carcinogenesis? I am currently researching the impact of environmental toxins on children's health and would greatly appreciate insights from...

02 August 2024 3,174 1 View

Could GSH level be more in CCL4 rats than negative control rats?

i compare between the antioxidant and oxidative stress level between negative control rats (saline) and CCL4 intoxicated rats. i found the level of GSH and TAC is more in toxic group than normal....

26 July 2024 1,887 0 View

Can we eliminate the stress singularity at the tip of the crack by manipulating the elastic constants?

The aim of the research here is to prevent the propagation of the crack in the fabricated elastic medium with useful applications.

25 July 2024 9,976 3 View

How to select relevant metabolites from multiple annotations ?

I am using the Polyomics Integrated Metabolomics Pipeline (PiMP) for metabolite feature analysis. After annotating my data, I have encountered cases where multiple potential metabolites are...

24 July 2024 5,789 0 View

How do nutrient transporters and aquaporins interact under abiotic stress in plants?

"The Correlation between Nutrition and Transport Mechanism under Abiotic Stress in Plants: A Comprehensive Review" by Muhammad Saleem, Jianhua Zhang, Muhammad Qasim, Rashid Iqbal, and Li Song,...

23 July 2024 9,109 0 View

Why not we are following sars COVID 19 guidance?

If the case of Irak is of December 2020 then i think I can suggest pl follow all the infection cause and death, already in our researchgate.

19 July 2024 3,356 2 View

How can alternative crops for augmenting farmers’ income in abiotic stress regions and impact of abiotic environmental stresses on crop quality?

13 July 2024 6,826 5 View

Please give me the scoring system of Academic stress scale developed by Rajendra and Kalikapan?

please give me the scoring system of Academic stress scale developed by Rajendra and Kalikapan?

11 July 2024 2,054 3 View

Is being an Assistant Professor in an university a stressful job?

I would like to know whether being an Assistant Professor in an university a highly stressful job or not?

09 July 2024 1,971 1 View

How are doctors coping with the challenges of sleep deprivation and the demands of performing multiple emergency surgeries?

How do the physical demands of performing multiple surgeries in a single shift affect a doctor's overall health and longevity? How does the quality of patient care change when doctors are working...

02 July 2024 9,470 0 View