Shail K Chaube

12 Questions 155 Answers 0 Followers

Questions related from Shail K Chaube

Up to what extent, the ovum factor is being considered important in IVF?

Ovum quality directly affects the fertilization rate and IVF outcome. Normally, based on few morphological criteria, ovum are sorted out from the pool of retried ovum. I would like to know the...

26 October 2021 4,291 0 View

Does oocyte generated from Oocyte like stem cell/neo-oogenesis/adult oogenesis is as good as natural oocytes?

Our long standing understanding for mammalian ovary is that it has fixed number of germ cells and duty of the ovary is to ovulate high quality ovum for successful fertilization and early embryonic...

12 October 2021 981 8 View

Similar to sperm funtion test, do we have scope to develop a oocyte function test for the management of women's egg factor issues?

As we know that the sperms function test is widely used for the management of male factor issues worldwide. However, similar parallel test is not available for the management of egg factor issue...

09 October 2021 4,356 2 View

Can the shape, number and distribution of mitochondria be used as a biomarker for oocyte quality?

Recent evidences suggest that mitochondria play important roles in determining the quality and fate of the oocytes in several mammalian species. Changes in shape, number as well as the...

06 October 2021 4,636 4 View

Which one is responsible for meiotic resumtion in mammalian oocytes i.e. "maturation promoting factor (MPF) activation or MPF destabilization?

The maturation promoting factor (MPF) is a key regulator of cell cycle that has regulatory subunit (Cyclins) and catalytic subunit (Cdks). Dissociation and degradation of specific cyclin...

30 September 2021 3,924 5 View

Is there any master switch that decides which death pathway will operate to eliminate a cell in mammalian tissue?

Type of insult (drugs, oxidants, intoxicants and other factors) and duration of exposure have been studies well to analyze the initiation of various death pathways (apoptosis, necrosis,...

14 June 2020 6,860 1 View

Can oocyte like cells generated through neo-oogensis undergo spontanous meiotic maturation in vitro?

Several studies indicate the presence of oogonial stem cells (OSCs) in postnatal mammalian ovaries. It has long been held that the ovaries contain a fixed number germ cells that remains...

06 June 2020 492 0 View

What structural differences enabled corina virus in rapid spread globally?

There are several pathogenic viruses but the way corona became pendemic remains mystry. Is it natural and came from animal origin or artificialy made so in the lab? Its spreading ability and...

19 May 2020 2,587 0 View

Does type and level of insult decide initiation of specific death pathway in mammalian cells?

Veriety of insult including stress initiate various death pathways in specific manner. It remains unclear whether specific type and its level decides which death pathway including PCD would be...

04 May 2020 3,698 0 View

Can we determine the fate of germ cells in mammalian ovary prior to ovulation?

Majority of female germ cells are eliminated from cohort of ovary and only few germ cells are culminated in oocyte and then ovum after ovulation.

02 May 2020 290 0 View

Which program cell death pathway play a major role in eliminating germ cell from mammalian ovary?

Several death pathways have been operated in mammalian ovary to selectivel eliminate surplus, defective, unwanted, damaged and abnormal germ cells from ovary but the contributiin of each pathway...

28 April 2020 3,651 0 View

Are specific phosohodiestrase inhibitors better drug of choice for targetting oocyte quality and fertility regulation?

Phopshodiesterse 3A and 9A inhibitors are specifically regulating oocyte physiology reversibly and have potential to be used as nonhormonal, reversible therapeutic drugs for ovarian functions.

28 April 2020 8,598 0 View